The Cox proportional hazards model restricts the log hazard ratio to be linear in the covariates. A smooth nonlinear covariate effect may go undetected in this model but can be well approximated by a ...

In this paper, a global goodness-of-fit test statistic for a Cox regression model, which has an approximate chi-squared distribution when the model has been correctly specified, is proposed. Our ...

Although Cox and logistic regression models have been compared previously in cohort studies, this work does not completely cover the GWAS setting nor extend to the case-cohort study design.