Replication itself causes a profound rearrangement in the chromatin structure, from nucleosomes to DNA loop domains, allowing to retain or switch an epigenetic state.

Histone acetylation increases the accessibility of DNA to interacting factors by destabilization of the nucleosome structure, and might locally alter chromatin at replication origins.

Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

In mitosis, DNA replication is initiated through the actions of various multiprotein complexes that recognize the start sites within a chromosome and cause the separation of DNA into two ...

Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. Scientists have determined at atomic resolution the structure of machinery ...

DNA replication likes one direction. Not the boy band, but rather it prefers to replicate in a certain direction over the other. Publishing their findings in Science Advances, scientists have ...

On the DNA assembly line, two proofreading proteins work together as an emergency stop button to prevent replication errors. New research from North Carolina State University and the University of ...

DNA Day is held on April 25 to commemorate the publishing of the scientific papers that described the helical structure of the DNA molecule ...

Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA replication.

They first determined the structure of the "Origin Recognition Complex" (ORC), a protein that identifies and attaches to specific DNA sites to initiate the entire replication process.

A new study has found that ORC plays a broad, unexpected role in regulating human cell gene expression and chromatin ...