Mouse jitters in League of Legends can be caused by dust on the mouse sensor or mouse pad, as well as faulty wireless transmitter/receiver and USB Port.

Are you experiencing the mouse moves on its own issue? When it comes to using a computer, having a mouse that moves on its own can be a frustrating and distracting problem. Troubleshooting this ...

Dirt could be covering the infrared sensor under your mouse. There could also be dirt inside the scroll wheel, in which case you’ll have to open the mouse with a screwdriver and use canned air ...