Moreover, amino acid supply via System L amino acid transporters underpins the metabolic reprogramming controlled by mTORC1, c-Myc and HIF1α in malignant T cells and is critical for the in vivo ...

Deprivation of one of the remaining essential amino acids gives either small responses or none at all. Supplementation of the methionine-free diet with cystine blocks the nucleolar enlargement and the ...