The selection of suitable outcomes and sample size calculation are critical factors in the design of a randomised controlled trial (RCT). The goal of this study was to identify the range of ...

Sample size calculations for planning these two-stage randomized trials with failure time outcomes are challenging because the variances of common test statistics depend in a complex manner on the ...

The educational field has now accumulated an extensive literature reporting on values of the intraclass correlation coefficient, a parameter essential to determining the required size of a planned ...

Background: In this article, we discuss the purpose of sample size calculation in clinical trials, the need for it, and the methods by which it is accomplished. Study samples that are either too ...

Nevertheless, several shortcomings of randomized clinical trials have been noted, including the need for a large sample size and long study duration, the lack of power to evaluate efficacy overall ...

Comparing results of a single-arm early-phase trial to those of a rigorously matched HCT ECA yielded insights regarding comparative efficacy prior to a randomized controlled trial. The effect size ...

Given the unacceptable quality of the sample size calculation of COVID-19 trials, I strongly suggest that all research teams include a statistician or invite a statistician to evaluate the ...

A sample size of 160 individuals (80 to each study arm) for this trial was determined on the basis of the F -test to detect a time by treatment group interaction effect at the 5% significance level ...

Some notes on the behaviour of sample size calculations and power for unequal group sizes This information was omitted from the video and so is included here as text. In many scenarios the ratio of ...