Cluster randomized trials (CRTs) represent a pivotal design in evaluating public health and clinical interventions where individuals are grouped into clusters (such as schools, hospitals or ...

Cluster randomised trials have diminishing returns in power and precision as cluster size increases. Making the cluster a lot larger while keeping the number of clusters fixed might yield only a very ...

Cluster randomized trials in health care may involve three instead of two levels, for instance, in trials where different interventions to improve quality of care are compared. In such trials, the ...

Members of the Ottawa Ethics of Cluster Randomized Trials Consensus Group participated in this project as individuals and not as representatives of their employers.

Methods TrACER was a cluster randomized trial where practices were randomized to usual care or a guideline-based SOE intervention. In the primary study, sites were randomized 3:1 to SOE of automated ...

In this cluster randomized trial of a breast cancer early diagnosis intervention in rural Rwanda, the training of CHWs, HC nurses, and hospital staff and establishment of regular breast clinics were ...

Methods/Design: This study will be a cluster-randomised controlled trial comparing screening and a subsequent risk tailored intervention for patients with low back pain to prevent chronic low back ...

A cluster-randomized design was chosen because the intervention was implemented hospital-wide; a crossover design was chosen to improve the power and statistical efficiency of the trial.

Heart failure affects over 64 million adults globally, with a population prevalence expected to rise dramatically in the coming decades.1 Despite the availability of medical therapies that improve ...