I know several languages that have the ability to use the Win32 API, but have no idea how to start learning it. I keep finding reasons to use the Win32API, and have no idea how to do so from VB ...

With Project Reunion, Microsoft has rolled up the Win32 API with the UWP API, so developers can add modern features like the Share panel to their desktop apps.

Windows 10 Creators Update can block Win32 apps if they’re not from the Store It appears to be an almost exact clone of macOS's Gatekeeper feature.